Neurotrophic keratopathy

Neurotrophic keratopathy; its pathophysiology and treatment.

Neurotropic keratopathy is one of the major refractory corneal disorders, which was first recognized in 1824. This category of diseases is caused by damage to the trigeminal nerve and the consequent loss of corneal sensation. It leads to various types of corneal disorder, including superficial keratopathy, persistent epithelial defects and corneal ulcers. In the present article, we review the p...

Corneal nerve regeneration in neurotrophic keratopathy following autologous plasma therapy.

AIMS To evaluate the effect of topical autologous plasma on nerve morphology in patients with neurotrophic keratopathy (NK) using the confocal microscope. METHODS Eleven eyes of six patients with neurotrophic keratopathy were evaluated for this study. Corneal fluorescein staining was done, and corneal sensitivity measurements were done with the Cochet-Bonnet and modified Belmonte gas aesthesiom...

[Effectiveness of topical autologous serum treatment in neurotrophic keratopathy].

OBJECTIVE To evaluate the effectiveness of 20% autologous serum as a treatment for neurotrophic keratopathy. MATERIAL AND METHODS A longitudinal, observational and descriptive study was performed on 19 patients (22 eyes) with neurotrophic keratopathy in different stages of Mackie's classification. The following variables were evaluated on the first visit, and then 4 months later: best correct...

Vitamin B12 Deficiency as a Cause of Neurotrophic Keratopathy

Introduction Neurotrophic keratitis is a rare degenerative corneal disease caused by an impairment of trigeminal corneal innervation, leading to a decrease or absence of corneal sensation. Here, we present a case of neurotrophic keratopathy caused by B12 deficiency in a 34 years old man who had a progressive decrease in visual acuity and corneal involvement since 3 months before being referred ...

Neurotrophic Keratopathy in Type I Familial Amyloidotic Polyneuropathy - a New Therapeutic Approach -